Cumulative behavioral and metabolic determinants of health are associated with higher inflammation-related indices: insights from a cross-sectional study (NHANES 2005–2018)
This cross-sectional study provides the first evidence that integrated BDoH-MDoH cumulative exposure models uncover distinct and synergistic inflammatory pathways. Both individual and combined behavioral-metabolic risk factors significantly associate with systemic inflammation biomarker elevation, highlighting the necessity of dual-target intervention strategies.
Authors
- Xiaoyun Lin (ORCID: https://orcid.org/0000-0002-5226-4521)
- Shenshen Du (ORCID: https://orcid.org/0000-0002-8417-2875)
- Anzhi Wang
- Xiaoyan Gao (ORCID: https://orcid.org/0000-0002-1656-2740)
- Ping Wang (ORCID: https://orcid.org/0000-0002-8640-1483)
- Yun Pan (ORCID: https://orcid.org/0000-0002-6328-7382)
- Yanxin Zeng
Institutions
- Zhujiang Hospital (CN)
- First Affiliated Hospital of Jinan University (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Frontiers in Public Health
- Published
- 2025-06-19
- DOI
- https://doi.org/10.3389/fpubh.2025.1602629
- Primary Topic
- Cardiovascular Health and Risk Factors
- Type
- article
- Field-Weighted Citation Impact
- 0.00