The Hedyotis diffusa chromosome-level genome and multi-omics analysis provide new insights into the iridoids biosynthetic pathway
This study provides the first T2T genome resource for <i>Hedyotis diffusa</i>, elucidating its unique WGD event and evolutionary trajectory. The tissue-specific expression patterns of MEP/MVA and iridoid biosynthesis genes suggest spatial regulation of metabolite production. The identification of LAMT and CYP71D55 homologs advances understanding of iridoid structural diversification. These findings establish a genomic foundation for further exploration of iridoid biosynthesis mechanisms and potential metabolic engineering applications.
Authors
- Kaiyu Zhu (ORCID: https://orcid.org/0000-0001-7364-1923)
- Lintao Han (ORCID: https://orcid.org/0000-0002-7858-6756)
- Mingzhu Yin (ORCID: https://orcid.org/0000-0002-6964-7131)
- Ping Huang (ORCID: https://orcid.org/0000-0003-1775-029X)
- Shihao Li (ORCID: https://orcid.org/0000-0001-6399-4039)
- B. N. Xiao
- Yuxin Wen (ORCID: https://orcid.org/0000-0002-2352-5622)
- Pengyu Chen (ORCID: https://orcid.org/0000-0002-3706-103X)
- Meng Chen (ORCID: https://orcid.org/0009-0009-5032-4429)
- Fang Huang (ORCID: https://orcid.org/0000-0003-3876-1123)
- Zhuang Huang (ORCID: https://orcid.org/0000-0003-4666-3267)
- Xing Hong
- Qi Jiang (ORCID: https://orcid.org/0009-0007-9498-5873)
- Rui Qian (ORCID: https://orcid.org/0009-0009-2324-0887)
Institutions
- Hubei University of Chinese Medicine (CN)
- Wuhan Ship Development & Design Institute (CN)
Publication Details
- Journal
- Frontiers in Plant Science
- Published
- 2025-06-19
- DOI
- https://doi.org/10.3389/fpls.2025.1607226
- Primary Topic
- Phytochemistry and Biological Activities
- Type
- article
- Field-Weighted Citation Impact
- 0.00