Tracing the evolutionary trajectory of the IncP-2 plasmid co-harboring blaIMP-45 and blaVIM-1: an outbreak of Pseudomonas aeruginosa co-producing IMP-45 and VIM-1 carbapenemases in China
This study reports a clonal outbreak of ST313 <i>P. aeruginosa</i> strains co-producing IMP-45 and VIM-1 carbapenemases in a tertiary hospital. The evolutionary path of the IncP-2 plasmid co-harboring <i>bla</i> <sub>IMP-45</sub> and <i>bla</i> <sub>VIM-1</sub> was elucidated.
Authors
- Hao Zu (ORCID: https://orcid.org/0000-0002-8707-1770)
- Yiqun Ma (ORCID: https://orcid.org/0000-0001-8346-7199)
- Zichen Lei
- Xinrui Yang (ORCID: https://orcid.org/0000-0002-2135-3425)
- Binghuai Lu (ORCID: https://orcid.org/0000-0003-3510-2747)
- Feilong Zhang (ORCID: https://orcid.org/0000-0002-9281-0742)
- Yulin Zhang (ORCID: https://orcid.org/0000-0002-3231-953X)
- Ziyao Li (ORCID: https://orcid.org/0000-0001-7346-2976)
- Qi Liu (ORCID: https://orcid.org/0009-0002-0475-3424)
Institutions
- Capital Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- China-Japan Friendship Hospital (CN)
- Peking Union Medical College Hospital (CN)
- National Clinical Research Center for Digestive Diseases (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-06-19
- DOI
- https://doi.org/10.3389/fcimb.2025.1623241
- Citations
- 3
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 1.77
Funders
- Chinese Academy of Medical Sciences