Effect of age on treatment outcomes of first‐line immune checkpoint inhibitor combination therapy for previously untreated advanced renal cell carcinoma

The effectiveness and safety profiles of first-line ICI combination therapy did not deteriorate, even in older patients. These findings suggest that ICI combination therapy for RCC should not be avoided because of chronological age alone. Geriatr Gerontol Int 2025; 25: 1082-1088.

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Publication Details

Journal
Geriatrics and gerontology international/Geriatrics & gerontology international
Published
2025-06-18
DOI
https://doi.org/10.1111/ggi.70105
Primary Topic
Renal cell carcinoma treatment
Type
article
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article

Effect of age on treatment outcomes of first‐line immune checkpoint inhibitor combination therapy for previously untreated advanced renal cell carcinoma

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1 links
Geriatrics and gerontology international/Geriatrics & gerontology international
Renal cell carcinoma treatment
article

Effect of age on treatment outcomes of first‐line immune checkpoint inhibitor combination therapy for previously untreated advanced renal cell carcinoma

Toshio Takagi, Koichi Nishimura, Kazuhiko Yoshida, Hironori Fukuda, Hiroki Ishihara, Yasunobu Hashimoto, Yuki Nemoto, Tsunenori Kondo, Hiroaki Shimmura, Junpei Iizuka, Shinsuke Mizoguchi, Takayuki Nakayama
article en

Abstract

The effectiveness and safety profiles of first-line ICI combination therapy did not deteriorate, even in older patients. These findings suggest that ICI combination therapy for RCC should not be avoided because of chronological age alone. Geriatr Gerontol Int 2025; 25: 1082-1088.

Geriatrics and gerontology international/Geriatrics & gerontology internationalVol. 25(8)
Jyoban Hospital of Tokiwa Foundation (JP), Tokyo Women's Medical University Adachi Medical Center (JP), Tokyo Women's Medical University (JP)
Good health and well-being
Openalex Percentile: Top 76%
Renal cell carcinoma treatment
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