Mechanisms Driving Altered Treatment Responses in Vulvar Dermatological Conditions with Autoimmune Components

Vulvar dermatological conditions, including lichen sclerosus, lichen planus, psoriasis, and eczema, often have autoimmune components influencing their pathophysiology and treatment responses.Patients with systemic autoimmune comorbidities frequently exhibit altered responses to standard therapies, suggesting a complex interplay between local and systemic immune mechanisms.This review explores the underlying immunological pathways, cytokine profiles, and genetic factors contributing to variable treatment outcomes in these conditions.By elucidating these mechanisms, we aim to inform personalized therapeutic strategies and highlight areas for future research.