Dysregulation of heterochromatin caused by genomic structural variants may be central to autism spectrum disorder
This study mechanistically links previously reported ASD-risk genes involved in chromatin remodeling with neurodevelopment and may explain the role of <i>de novo</i> mutations in ASD. Our results suggest that a large portion of the heritable component of autism is the result of changes in genes that control critical epigenetic processes.
Authors
- Michael R. Garvin (ORCID: https://orcid.org/0000-0002-2204-7569)
- David Kainer (ORCID: https://orcid.org/0000-0001-7271-4676)
Institutions
- Oak Ridge National Laboratory (US)
- University of New Mexico (US)
- ARC Centre of Excellence for Plant Success in Nature and Agriculture (AU)
Publication Details
- Journal
- Frontiers in Molecular Neuroscience
- Published
- 2025-06-19
- DOI
- https://doi.org/10.3389/fnmol.2025.1553575
- Citations
- 1
- Primary Topic
- Genomic variations and chromosomal abnormalities
- Type
- article
- Field-Weighted Citation Impact
- 1.82
Funders
- National Institutes of Health