Rethinking phenylalanine levels in phenylketonuria for optimal neurocognitive development beyond childhood
These findings underscore the detrimental effects of elevated Phe levels on executive functions during adolescence and highlight the need for larger studies to determine whether blood Phe levels between 360 and 600 µM are safe for patients aged >12 years.
Authors
- N. Correia (ORCID: https://orcid.org/0000-0003-4852-9985)
- Cristina Florindo (ORCID: https://orcid.org/0000-0002-0664-5411)
- Miranildes de Abreu Batista
- Ana Gaspar (ORCID: https://orcid.org/0000-0003-3979-9924)
- Patrícia Janeiro (ORCID: https://orcid.org/0000-0002-8985-1156)
- Cláudia Bandeira de Lima (ORCID: https://orcid.org/0000-0001-8427-3185)
- Inês Fernandes (ORCID: https://orcid.org/0000-0002-0173-2823)
- Beatriz Câmara
Institutions
- University of Lisbon (PT)
- Hospital de Santa Maria (PT)
- Hospital Dr. Nélio Mendonça (PT)
Publication Details
- Journal
- Frontiers in Pediatrics
- Published
- 2025-06-19
- DOI
- https://doi.org/10.3389/fped.2025.1488809
- Citations
- 1
- Primary Topic
- Metabolism and Genetic Disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.32
Funders
- Universidade de Lisboa