Normal values of high-resolution transmural perfusion distribution metrics for automated quantitative pixel-wise myocardial perfusion cardiovascular magnetic resonance
Normal global and myocardial slice-specific values of MPR<sub>ENDO</sub>, MPR<sub>EPI</sub>, sGRAD and rGRAD using in-line automated MBF quantification from first pass myocardial perfusion CMR are presented. While there were no sex-specific differences in any of these metrics, all correlated inversely with increasing age. Understanding the MBF dynamics of the myocardial layers in healthy subjects will help to characterize MBF alterations in patients with coronary artery disease or microvascular dysfunction.
Authors
- Noor Sharrack (ORCID: https://orcid.org/0000-0001-5880-1722)
- Christel H. Kamani (ORCID: https://orcid.org/0000-0002-0924-7910)
- John Pierre Greenwood (ORCID: https://orcid.org/0000-0002-2861-0914)
- Ioannis Botis (ORCID: https://orcid.org/0000-0003-0582-2006)
- Arka Das (ORCID: https://orcid.org/0000-0003-1134-3036)
- Eylem Levelt (ORCID: https://orcid.org/0000-0002-3799-7102)
- Nicholas Jex (ORCID: https://orcid.org/0000-0001-9395-584X)
- Peter Kellman (ORCID: https://orcid.org/0000-0002-9875-6070)
- Gaurav Singh Gulsin (ORCID: https://orcid.org/0000-0002-1740-9270)
- Gerry P McCann (ORCID: https://orcid.org/0000-0002-5542-8448)
- Amrit Chowdhary (ORCID: https://orcid.org/0000-0002-2073-4138)
- Thomas Anderton (ORCID: https://orcid.org/0000-0001-8102-0692)
- Sharmaine Thirunavukarasu (ORCID: https://orcid.org/0000-0003-2535-8407)
- Peter Swoboda (ORCID: https://orcid.org/0000-0001-7162-7079)
- Jian L Yeo (ORCID: https://orcid.org/0000-0001-8324-4286)
- Hui Xue (ORCID: https://orcid.org/0000-0002-4561-5530)
- Louise Brown (ORCID: https://orcid.org/0000-0002-1327-6482)
- Christopher Saunderson (ORCID: https://orcid.org/0000-0002-1955-2126)
- David Adlam (ORCID: https://orcid.org/0000-0002-0080-9884)
- Sven Plein (ORCID: https://orcid.org/0000-0002-0997-4384)
- Raluca Tomoaia (ORCID: https://orcid.org/0000-0002-1944-4088)
- David Broadbent (ORCID: https://orcid.org/0000-0002-5892-4762)
- Alice L Wood
- Chin Soo
Institutions
- National Institutes of Health (US)
- University of Leeds (GB)
- Iuliu Hațieganu University of Medicine and Pharmacy (RO)
- Leeds Teaching Hospitals NHS Trust (GB)
- Glenfield Hospital (GB)
- National Heart, Lung, and Blood Institute (US)
- NIHR Leicester Cardiovascular Biomedical Research Unit (GB)
- NIHR Leicester Biomedical Research Centre (GB)
- Leeds Dental Hospital (GB)
- University of Lausanne (CH)
Publication Details
- Journal
- Journal of Cardiovascular Magnetic Resonance
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.jocmr.2025.101927
- Primary Topic
- Cardiac Imaging and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Wellcome Trust
- National Institute for Health and Care Research
- Department of Health and Social Care
- Leeds Biomedical Research Centre
- NIHR Leicester Biomedical Research Centre