Loss of apolipoprotein E contributes to inflammatory macrophage activation and ferroptosis in NSAID-exacerbated respiratory disease
Our results suggest a role for myeloid ApoE in regulating the cross talk between macrophages and epithelial cells, as well as in ferroptosis during type 2 airway inflammation. ApoE deficiency may thus contribute to chronic type 2 inflammation in patients with N-ERD, and its restoration could help reestablish normal epithelial barrier integrity and macrophage effector functions.
Authors
- Sonja Schindela
- Antonie Lechner (ORCID: https://orcid.org/0000-0002-1636-3354)
- Manuel Kulagin
- Zhigang Rao (ORCID: https://orcid.org/0000-0002-9918-9100)
- Franziska Hartung (ORCID: https://orcid.org/0000-0001-5660-2324)
- Andreas Koeberle (ORCID: https://orcid.org/0000-0001-6269-5088)
- Pascal Haimerl (ORCID: https://orcid.org/0000-0002-0974-2970)
- Adam Chaker (ORCID: https://orcid.org/0000-0002-5117-4073)
- Julia Esser‐von Bieren (ORCID: https://orcid.org/0000-0003-1898-9382)
- Fiona Henkel
- Carsten B. Schmidt‐Weber (ORCID: https://orcid.org/0000-0002-3203-8084)
- Benedikt Spitzlberger (ORCID: https://orcid.org/0009-0005-5791-5118)
- Gilles Schmiz
- Isika Ram
Institutions
- Universität Innsbruck (AT)
- Helmholtz Zentrum München (DE)
- Technical University of Munich (DE)
- University of Lausanne (CH)
Publication Details
- Journal
- Journal of Allergy and Clinical Immunology
- Published
- 2025-06-19
- DOI
- https://doi.org/10.1016/j.jaci.2025.06.010
- Citations
- 1
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 1.52
Funders
- Deutsche Forschungsgemeinschaft
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Austrian Science Fund
- Else Kröner-Fresenius-Stiftung
- Fritz Thyssen Stiftung
- Tiroler Wissenschaftsförderung
- Phospholipid Research Center
- Deutsche Akademie der Naturforscher Leopoldina - Nationale Akademie der Wissenschaften
- Deutsches Forschungszentrum für Gesundheit und Umwelt, Helmholtz Zentrum München