Rebaudioside D and M, the next-generation sugar substitutes, do not exacerbate metabolic dysfunction in high-fat diet mice

As concerns about sugar-sweetened beverages are increasing, interest in natural sweeteners with zero calories is also growing. This study explores the health impacts of rebaudioside D and M, emerging sugar substitutes, compared to traditional alternatives and stevioside. In mouse models, we investigated the effects of rebaudioside D and M on obesity, liver health, thermogenic adipocytes, skeletal muscle, and gut microbiota. Results show no weight gain or exacerbation of obesity, no promotion of hepatic steatosis, no impairment of brown adipose tissue function and no changes in skeletal muscle metabolic proteins with either rebaudioside. Importantly, both of these sugar substitutes positively influence gut microbiota without adverse metabolic effects, suggesting their potential as safe sugar alternatives.

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Publication Details

Journal
Food Chemistry X
Published
2025-06-19
DOI
https://doi.org/10.1016/j.fochx.2025.102679
Citations
1
Primary Topic
Diet, Metabolism, and Disease
Type
article
Field-Weighted Citation Impact
1.29

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article

Rebaudioside D and M, the next-generation sugar substitutes, do not exacerbate metabolic dysfunction in high-fat diet mice

Bu-Soo Park, Junhyeong Lee, Seong‐Jin Hong, Ki‐Nam Yoon et al.
1 citations
Food Chemistry X
Diet, Metabolism, and Disease
1.29
article

Rebaudioside D and M, the next-generation sugar substitutes, do not exacerbate metabolic dysfunction in high-fat diet mice

Bu-Soo Park, Junhyeong Lee, Seong‐Jin Hong, Ki‐Nam Yoon, Merc Emil Matienzo, Young‐Min Kim, Dong‐Il Kim, Keon Kim, Min-Jung Park, Chang‐Min Lee, Y.J. Baek, Sangyi Lim
article en
1 citations

Abstract

As concerns about sugar-sweetened beverages are increasing, interest in natural sweeteners with zero calories is also growing. This study explores the health impacts of rebaudioside D and M, emerging sugar substitutes, compared to traditional alternatives and stevioside. In mouse models, we investigated the effects of rebaudioside D and M on obesity, liver health, thermogenic adipocytes, skeletal muscle, and gut microbiota. Results show no weight gain or exacerbation of obesity, no promotion of hepatic steatosis, no impairment of brown adipose tissue function and no changes in skeletal muscle metabolic proteins with either rebaudioside. Importantly, both of these sugar substitutes positively influence gut microbiota without adverse metabolic effects, suggesting their potential as safe sugar alternatives.

Food Chemistry XVol. 29
Chonnam National University (KR), Korea University (KR), Samsung (South Korea) (KR)
Ministry of Trade, Industry and Energy, National Research Foundation of Korea, National Research Council of Science and Technology, Ministry of Science and ICT, South Korea
Zero hunger
Openalex Percentile: Top 18%
Diet, Metabolism, and Disease
1.29
DOIOpen Access PDFOpenAlex
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