Persistent Chronic Thrombo-Inflammation in Anti–Glomerular Basement Membrane Disease Despite Immune Complex Removal
Circulating HGFs, proinflammatory cytokines, and platelet activation markers are important biomarkers of anti-GBM disease activity. Chronic platelet activation, persists independently of anti-GBM antibody integrity, highlighting the need for therapies targeting thrombo-inflammation.
Authors
- Johan Mölne (ORCID: https://orcid.org/0000-0001-6241-7117)
- Mélodie Douté (ORCID: https://orcid.org/0000-0002-1926-9718)
- Mårten Segelmark (ORCID: https://orcid.org/0000-0002-1221-0772)
- Antonino Nicoletti (ORCID: https://orcid.org/0000-0002-2623-0897)
- Marc Clément (ORCID: https://orcid.org/0000-0002-6479-8360)
- Linnéa Tyrberg (ORCID: https://orcid.org/0009-0002-5446-6546)
- Ingeborg M. Bajema
- Giuseppina Caligiuri (ORCID: https://orcid.org/0000-0003-4973-2205)
- Younès Youssfi (ORCID: https://orcid.org/0000-0002-1976-9931)
Institutions
- University Medical Center Groningen (NL)
- Inserm (FR)
- University of Groningen (NL)
- Lund University (SE)
- Université Paris Cité (FR)
- Sahlgrenska University Hospital (SE)
- Sorbonne Université (FR)
- Université Sorbonne Paris Nord (FR)
- Laboratoire Excell (FR)
- Region Västra Götaland (SE)
- Assistance Publique – Hôpitaux de Paris (FR)
- Hôpitaux Universitaires Paris-Ouest (FR)
- Helsingborgs lasarett (SE)
- Laboratoire de Recherche Vasculaire Translationnelle (FR)
- Skåne University Hospital (SE)
Publication Details
- Journal
- Kidney International Reports
- Published
- 2025-06-19
- DOI
- https://doi.org/10.1016/j.ekir.2025.06.014
- Primary Topic
- Vasculitis and related conditions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Laboratoire d'Excellence Inflamex
- Agence Nationale de la Recherche
- Institut National de la Santé et de la Recherche Médicale
- Fondation pour la Recherche Médicale
- Ingrid Asps Stiftelser