Causal role of endothelial dysfunction in ischemic stroke and its subtypes: A two-stage analysis
This work offers causal evidence that endothelial dysfunction significantly contributes to IS, highlighting the thrombotic activity of vWF in CES and the inflammatory function of E-selectin in LAS. These findings not only offer valuable insights into the mechanisms underlying IS and its subtypes but also help inform personalized stroke prevention strategies.
Authors
- Qian Wu (ORCID: https://orcid.org/0000-0002-8912-0118)
- Chongge You (ORCID: https://orcid.org/0000-0002-3671-596X)
- Xiaoxin Li (ORCID: https://orcid.org/0000-0002-5161-9458)
- Jingjing Cui
- Yao Jiang (ORCID: https://orcid.org/0000-0002-5254-550X)
Institutions
- Gansu Provincial Hospital (CN)
- Lanzhou University Second Hospital (CN)
- Shaanxi University of Chinese Medicine (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- SLAS TECHNOLOGY
- Published
- 2025-06-19
- DOI
- https://doi.org/10.1016/j.slast.2025.100322
- Citations
- 4
- Primary Topic
- Protease and Inhibitor Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 3.75
Funders
- Lanzhou University
- Natural Science Foundation of Shaanxi Province