Creatinine promotes adipose tissue wasting in chronic kidney disease via creatine and futile creatine cycle
Our results show that elevated serumal creatinine induces creatine accumulation, FCC activation and adipose tissue wasting in CKD, targeting creatinine-induced tissue wasting providing a promising therapeutic to ameliorate cachexia in CKD.
Authors
- Hanying Ding (ORCID: https://orcid.org/0000-0002-0155-6057)
- Chunli Guo
- Min Zheng (ORCID: https://orcid.org/0000-0002-0329-9680)
- Xiaobing Yang (ORCID: https://orcid.org/0000-0002-7560-8673)
- Jingwen Fang (ORCID: https://orcid.org/0000-0001-7906-8152)
- Ting Chen (ORCID: https://orcid.org/0000-0001-8648-7136)
- Yubing Chen (ORCID: https://orcid.org/0009-0008-5407-7683)
- Xian-Fen Huang
Institutions
- Southern Medical University (CN)
Publication Details
- Journal
- Molecular Metabolism
- Published
- 2025-06-19
- DOI
- https://doi.org/10.1016/j.molmet.2025.102191
- Citations
- 2
- Primary Topic
- Muscle metabolism and nutrition
- Type
- article
- Field-Weighted Citation Impact
- 2.30
Funders
- National Natural Science Foundation of China
- Guangdong Provincial Key Laboratory of Prevention and Control for Severe Clinical Animal Diseases
- Guangzhou Science and Technology Program key projects