Epidemiology of aminoglycosides resistance and phenotypic detection of aac(6′)-Ib-cr gene in ESBL-producing Enterobacterales in febrile urinary tract infection in children
The low amikacin resistance in ESBL-E supports its continued use as a reliable empiric treatment for pediatric FUTIs. However, the aac(6')-Ib-cr gene can raise amikacin MICs, potentially compromising efficacy in high-inoculum infections despite EUCAST susceptibility. Our phenotypic algorithm helps detect it and guide treatment decisions for pediatric FUTIs.
Authors
- Audrey Baron (ORCID: https://orcid.org/0000-0001-8366-597X)
- Philippe Bidet (ORCID: https://orcid.org/0009-0009-8615-4695)
- Elsa Sobral
- Camille Jung (ORCID: https://orcid.org/0000-0001-8486-8939)
- Robert Cohen (ORCID: https://orcid.org/0000-0001-6151-0686)
- Kévin La (ORCID: https://orcid.org/0009-0009-4200-2606)
- André Birgy (ORCID: https://orcid.org/0000-0001-9462-0582)
- Fouad Madhi (ORCID: https://orcid.org/0000-0001-6816-5272)
- Corinne Levy (ORCID: https://orcid.org/0000-0002-5325-5838)
- Stéphane Bonacorsi
- Yasmine Benhadid-Brahmi (ORCID: https://orcid.org/0000-0002-8147-873X)
Institutions
- Inserm (FR)
- Université Paris Cité (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Hôpital Robert-Debré (FR)
- Association Française de Pédiatrie Ambulatoire (FR)
- Association Clinique et Thérapeutique Infantile du Val de Marne (FR)
- Hôpital Intercommunal de Créteil (FR)
- Institut Mondor de Recherche Biomédicale (FR)
Publication Details
- Journal
- Journal of Global Antimicrobial Resistance
- Published
- 2025-06-19
- DOI
- https://doi.org/10.1016/j.jgar.2025.06.008
- Citations
- 1
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.59