Computationally Modeling the Physiologic Impact of the Ratio of Fats to Carbohydrates in the Diet on Intake Among Metabolically Healthy Adults
Eating a diet with ≥40% of its energy from fats relative to carbohydrates can achieve the largest reductions in total calories consumed and late-night snacking each day than consuming higher proportions of carbohydrates, with even further reductions as more fat is added to the diet, when considering the physiologic responses to dietary intake alone. Future research should layer in other strong contributing factors to eating such as stress, social context, palatability, physical activity, and types of macronutrients, and also represent other metabolic profiles and ages.
Authors
- Sarah L. Booth (ORCID: https://orcid.org/0000-0002-1525-4025)
- Jennifer J. Lee (ORCID: https://orcid.org/0000-0002-9381-2280)
- José M. Ordovás (ORCID: https://orcid.org/0000-0002-7581-5680)
- Sheryl A. Scannell (ORCID: https://orcid.org/0000-0003-2784-6279)
- Kayla de la Haye (ORCID: https://orcid.org/0000-0002-2536-7701)
- Britt Burton‐Freeman (ORCID: https://orcid.org/0000-0002-3754-9852)
- Timothy H. Moran (ORCID: https://orcid.org/0000-0001-9877-8723)
- Marie F. Martinez (ORCID: https://orcid.org/0000-0002-8725-1894)
- Kevin L. Chin (ORCID: https://orcid.org/0000-0001-8715-7016)
- Jessie Heneghan (ORCID: https://orcid.org/0009-0007-5274-9864)
- Bruce Y. Lee (ORCID: https://orcid.org/0000-0003-2633-8651)
- Kavya Velmurugan
- Alexis Dibbs (ORCID: https://orcid.org/0009-0001-5871-6023)
- Colleen Weatherwax (ORCID: https://orcid.org/0000-0001-5929-518X)
- Tej D. Shah
- S. J. Kleinberg
- Sarah M. Bartsch
Institutions
- Stevens Institute of Technology (US)
- University of Southern California (US)
- The Graduate Center, CUNY (US)
- Tufts University (US)
- Johns Hopkins University (US)
- Illinois Institute of Technology (US)
- Jean Mayer Human Nutrition Research Center on Aging (US)
- Nutrition Sciences (Belgium) (BE)
Publication Details
- Journal
- Current Developments in Nutrition
- Published
- 2025-06-19
- DOI
- https://doi.org/10.1016/j.cdnut.2025.107487
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Science Foundation
- National Institutes of Health
- Agency for Healthcare Research and Quality
- National Institute of General Medical Sciences
- National Center for Advancing Translational Sciences
- Common Fund