Myeloid TGF-β signaling shapes liver macrophage heterogeneity and metabolic liver disease pathogenesis
Our study reveals that myeloid TGF-β signaling plays a crucial role in shaping liver macrophage heterogeneity, which in turn influences the pathogenesis of metabolic liver disease. These findings are particularly important for researchers studying immune-metabolic interactions and for clinicians seeking new therapeutic strategies for liver disorders. By elucidating how TGF-β signaling regulates macrophage function, our work paves the way for targeted interventions that modulate immune responses to improve liver health. Future research should consider the potential translational applications of these findings while addressing limitations related to model systems and human variability.
Authors
- Katherine Ann Gallagher (ORCID: https://orcid.org/0000-0002-8791-6980)
- Yu-Tung Lee
- You Lu (ORCID: https://orcid.org/0000-0002-0075-8167)
- Benjamin Lévi (ORCID: https://orcid.org/0000-0001-8272-7139)
- Linkang Zhou (ORCID: https://orcid.org/0000-0002-7009-5776)
- Jiandie D. Lin (ORCID: https://orcid.org/0000-0001-8069-5647)
- Ziyi Meng (ORCID: https://orcid.org/0000-0002-8441-5670)
- Xiaoxue Qiu (ORCID: https://orcid.org/0000-0002-1015-9993)
- Zhimin Chen (ORCID: https://orcid.org/0000-0003-4241-7122)
- Tongyu Liu (ORCID: https://orcid.org/0000-0002-8579-2144)
- Siming Li (ORCID: https://orcid.org/0000-0001-9498-9689)
Institutions
- University of Michigan (US)
- Organogenesis (United States) (US)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- JHEP Reports
- Published
- 2025-06-19
- DOI
- https://doi.org/10.1016/j.jhepr.2025.101488
- Citations
- 3
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 4.06
Funders
- American Heart Association
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases