Pre-hyperuricemia: The silent precursor to metabolic disorders

The global prevalence of hyperuricemia has been rapidly increasing over the past two decades, primarily due to changes in dietary habits and lifestyle. Recent research has unveiled a strong association between hyperuricemia and various non-communicable diseases, suggesting that uric acid-induced systemic inflammation and endothelial dysfunction may begin even before reaching the current diagnostic threshold for hyperuricemia. This review introduces the concept of “pre-hyperuricemia,” defined as a high normal serum uric acid level, and explores its potential role as an early indicator and risk factor for metabolic disorders. We have discussed the molecular mechanisms underlying uric acid-induced inflammation, the epidemiology of hyperuricemia, and its associations with various extra-articular diseases. Furthermore, we have emphasized the importance of early detection and management of pre-hyperuricemia through lifestyle modifications to prevent the development and progression of uric acid-related diseases.