Association of item‐level responses to cognitive function index with tau pathology and hippocampal volume in the A4 Study
Higher tau in the medial temporal lobe (tau<sub>MTL</sub>) was linked to participant-reported memory and orientation decline such as needing reminders or getting lost.Higher tau<sub>MTL</sub> was associated with increased memory-related concerns, such as needing help with appointments and asking repetitive questions.Lower hippocampal volume was associated with spatial memory and navigation such as driving difficulties and greater memory decline as reported by study partners.
Authors
- Ali Ezzati (ORCID: https://orcid.org/0000-0003-1307-4589)
- İdris Demirsoy (ORCID: https://orcid.org/0000-0002-3321-4748)
- Bhargav Teja Nallapu (ORCID: https://orcid.org/0000-0001-6368-8509)
- Babak Khorsand (ORCID: https://orcid.org/0000-0002-1585-3909)
- S. Ahmad Sajjadi (ORCID: https://orcid.org/0000-0002-8960-2213)
- Kellen K. Petersen (ORCID: https://orcid.org/0000-0003-3195-3456)
- Laura A. Rabin
- Elham Ghanbarian
- Richard Lipton
Institutions
- The Graduate Center, CUNY (US)
- Albert Einstein College of Medicine (US)
- University of California, Irvine (US)
- Washington University in St. Louis (US)
- Brooklyn College (US)
Publication Details
- Journal
- Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1002/dad2.70128
- Citations
- 1
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- Alzheimer's Association
- Cure Alzheimer's Fund
- National Institutes of Health
- National Institute on Aging