Spectrum of resistance to antibacterial drugs of <i>Staphylococcus spp</i>. isolates depending on the ability to form biofilms

The paper presents the results of studying the spectrum of resistance to antibacterial drugs of Staphylococcus spp. isolates depending on their ability to form biofilms. Two methodological approaches were used to determine the causes of the low efficiency of antibiotic therapy used in livestock farms. The sensitivity of the isolated staphylococci to antibiotics was determined and the ability of these cultures to form biofilms was established. It was found that staphylococci isolated from goats were resistant mainly (more than 50% of isolates) to tylosin, penicillin, clindamycin, amikacin, lincomycin, gentamicin, meropenem and levofloxacin, from cattle - to azithromycin, clindamycin, meropenem, rifampicin, amikacin, and from poultry - to tylosin, penicillin, tetracycline, doxycycline, amikacin, azithromycin, clindamycin, ciprofloxacin, cefotaxime, lincomycin and gentamicin. It was found that all strains had multiple drug resistance to two or more groups of antibiotics. It was found that 60-67% of microorganism strains were potentially capable of forming biofilms. It has been proven that positive results of antibiotic susceptibility tests in vitro cannot be extrapolated to the predicted effectiveness of these drugs in vivo. The need to study isolated staphylococcal strains for antibiotic sensitivity and their ability to form a biofilm when selecting an optimal treatment regimen for farm animals and poultry is substantiated.