Changes in blood leukogram during the treatment of purulent otitis in rabbits by using different methods

The article examines the therapeutic efficacy of various treatment methods in experimentally induced purulent otitis in rabbits. The condition was artificially induced by introducing pure microbial isolates, obtained from the purulent exudates of rabbits with otitis, into the ears of healthy rabbits. It was established that the application of 0.25% levomycetin alcohol, dioxidine, chymotrypsin, hydrocortisone, adrenaline, fluconazole, and cefotaxime-BHF3, in specific doses and sequences, led to a significant reduction in the duration of purulent otitis treatment. Hematological analysis showed an increase in eosinophils, segmented neutrophils, and monocytes, along with a decrease in lymphocytes in the leukogram. Based on the conducted experiments, it was concluded that the effectiveness of the administered drugs could be evaluated through changes in blood parameters. Additionally, no clinical signs of otitis were observed in the treated rabbits.