Diamond Molecular Balance: Ultra-Wide Range Nanomechanical Mass Spectrometry from MDa to TDa
The significance of mass spectrometry lies in its unparalleled ability to accurately identify and quantify molecules in complex samples, providing invaluable insights into molecular structures and interactions. Here, we leverage diamond nanostructures as highly sensitive mass sensors by utilizing a self-excitation mechanism under an electron beam in a conventional scanning electron microscope (SEM). The diamond molecular balance (DMB) exhibits a practical mass resolution of 4.07 MDa, based on its notable mechanical quality factor and frequency stability, along with a broad dynamic range from MDa to TDa. This positions the DMB at the forefront of nanoelectromechanical system (NEMS)-based mass spectrometry operating at room temperature. Notably, the DMB demonstrated its ability to measure the mass of a single bacteriophage T4 by precisely locating the analyte on the device. These findings demonstrate the capability and potential of the DMB as a revolutionary tool for mass spectrometry at room temperature.
Authors
- Hojoong Jung (ORCID: https://orcid.org/0000-0001-7059-1713)
- Jae‐Pyoung Ahn (ORCID: https://orcid.org/0000-0003-2657-7425)
- Jinwoong Cha (ORCID: https://orcid.org/0000-0002-1380-4345)
- Cherlhyun Jeong (ORCID: https://orcid.org/0000-0002-7584-3059)
- Il‐Young Kim (ORCID: https://orcid.org/0000-0002-6314-2415)
- Hee Chul Park
- Dongyeon Daniel Kang (ORCID: https://orcid.org/0000-0001-7778-3195)
- Seung‐Bo Shim (ORCID: https://orcid.org/0000-0001-5488-2983)
- Sang‐Hun Lee (ORCID: https://orcid.org/0000-0002-0830-7862)
- Yanghee Kim (ORCID: https://orcid.org/0009-0008-5941-5899)
- Chulki Kim (ORCID: https://orcid.org/0000-0002-9806-5122)
- Donggeun Lee (ORCID: https://orcid.org/0000-0003-1994-1540)
- Chang-Hwan Yi
- Yeeun Choi
- Sang-Wook Han
- Seung‐Woo Jeon
- Junho Suh
Institutions
- Kumoh National Institute of Technology (KR)
- University of Science and Technology (YE)
- Pohang University of Science and Technology (KR)
- Korea University (KR)
- Korea Research Institute of Standards and Science (KR)
- Center for Theoretical Physics (PL)
- Quantum (Australia) (AU)
- Integra (United States) (US)
- Institute for Basic Science (KR)
- Quantum Technology Sciences (United States) (US)
- Bio-Medical Science (South Korea) (KR)
- Korea Institute of Science and Technology (KR)
- Korea University of Science and Technology (KR)
- Pukyong National University (KR)
Publication Details
- Journal
- Nano Letters
- Published
- 2025-06-19
- DOI
- https://doi.org/10.1021/acs.nanolett.5c02032
- Citations
- 2
- Primary Topic
- Mechanical and Optical Resonators
- Type
- article
- Field-Weighted Citation Impact
- 2.49
Funders
- Korea Institute of Science and Technology
- National Research Foundation of Korea
- Ministry of Science and ICT, South Korea