Photocatalyzed <sup>18</sup>F-Fluorination: A Streamlined Radiolabeling Approach for Rapid Adoption and Automation
In this work, we established a simplified photoredox-mediated labeling system that allows the rapid aryl <sup>18</sup>F-fluorination of functional electron-neutral and electron-rich arenes via <sup>19</sup>F-<sup>18</sup>F exchange and/or deoxyfluorination without azeotropic drying, applying a HPO<sub>4</sub><sup>2-</sup> preconditioned anion exchange resin. The labeling reaction can be performed with the whole eluted <sup>18</sup>F<sup>-</sup> other than a portion and has been verified on a radiosynthesis module. The simple reaction setup with all commercially available reagents and inexpensive equipment guarantees reproducibility and quick adoption.
Authors
- Zheng Cheng (ORCID: https://orcid.org/0000-0002-3887-3662)
- Lili Pan (ORCID: https://orcid.org/0000-0003-3903-071X)
- Xiaoai Wu (ORCID: https://orcid.org/0000-0002-3518-9689)
- Haoxing Wu (ORCID: https://orcid.org/0000-0002-0008-4668)
- Mufeng Li
- Wei Chen (ORCID: https://orcid.org/0000-0002-3694-5204)
- Hongbao Sun (ORCID: https://orcid.org/0000-0002-7956-0232)
- Cheng Yang (ORCID: https://orcid.org/0000-0002-2049-1324)
- Yueqi Wang (ORCID: https://orcid.org/0000-0002-0374-1045)
- Kai Lu (ORCID: https://orcid.org/0000-0002-1177-9369)
- Yang Xie
- Mingxing Hu
Institutions
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-06-19
- DOI
- https://doi.org/10.1021/acs.orglett.5c02193
- Citations
- 7
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 5.54
Funders
- Nuclear Power Institute of China
- National Natural Science Foundation of China
- Department of Science and Technology of Sichuan Province
- Sichuan University
- West China Hospital, Sichuan University