Cannabis tolerance reduces symptom relief
The findings suggest the majority of patients experience decreased symptom relief after repeated use of medical cannabis, counterbalanced by improvements in negative side effects. Of direct clinical relevance, THC levels and the dose can be adjusted to customize medical cannabis patient treatment, increase medication compliance, and improve treatment outcomes.
Authors
- Franco Brockelman (ORCID: https://orcid.org/0000-0002-8876-6179)
- Branden Hall (ORCID: https://orcid.org/0000-0002-4390-6000)
- Keenan Keeling (ORCID: https://orcid.org/0000-0002-3117-3313)
- Sarah S. Stith (ORCID: https://orcid.org/0000-0003-0311-5674)
- Jacob M. Vigil (ORCID: https://orcid.org/0000-0002-8534-2215)
- Xiaoxue Li (ORCID: https://orcid.org/0000-0003-1240-8903)
Institutions
- University of New Mexico (US)
- Hyattsville Community Development Corporation (US)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-06-19
- DOI
- https://doi.org/10.3389/fphar.2025.1496232
- Citations
- 1
- Primary Topic
- Cannabis and Cannabinoid Research
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- Marshfield Clinic Research Foundation