Age-dependent response to initial highly effective treatment in relapsing multiple sclerosis
This real-world study of relapsing pwMS demonstrates that the benefit of initial HE treatment diminishes with age. However, even in older patients, DMT exposure, regardless of the efficacy level, appears to reduce disability accumulation, and so, on an individual level, initial HE treatment could still be more effective.
Authors
- Massimo Filippi (ORCID: https://orcid.org/0000-0002-5485-0479)
- Mauro Zaffaroni (ORCID: https://orcid.org/0000-0001-9020-934X)
- Diana Ferraro (ORCID: https://orcid.org/0000-0003-4818-3806)
- Carla Tortorella (ORCID: https://orcid.org/0000-0001-9037-7300)
- María Trojano (ORCID: https://orcid.org/0000-0002-6329-8946)
- Lorenzo Razzolini (ORCID: https://orcid.org/0000-0002-7127-3386)
- Alessandra Lugaresi (ORCID: https://orcid.org/0000-0003-2902-5589)
- Emilio Portaccio (ORCID: https://orcid.org/0000-0002-9662-1762)
- Alessia Di Sapio (ORCID: https://orcid.org/0000-0002-5575-7567)
- Maria Pia Amato (ORCID: https://orcid.org/0000-0003-3325-3760)
- Pietro Iaffaldano (ORCID: https://orcid.org/0000-0003-2308-1731)
- Gioacchino Tedeschi
- Sara Montepietra
- Giovanna De Luca (ORCID: https://orcid.org/0000-0002-7693-2256)
- Luisa Pastò
- Ermelinda De Meo (ORCID: https://orcid.org/0000-0001-5531-1111)
- Marta Simone (ORCID: https://orcid.org/0000-0003-4381-4613)
- Francesco Patti (ORCID: https://orcid.org/0000-0002-6923-0846)
- Giuseppe Salemi (ORCID: https://orcid.org/0000-0002-3756-4323)
- Carlo Pozzilli (ORCID: https://orcid.org/0000-0002-6360-4798)
- Giacomo Lus (ORCID: https://orcid.org/0000-0002-9457-1124)
- Eleonora E. Cocco (ORCID: https://orcid.org/0000-0002-3878-8820)
- Vincenzo Brescia Morra (ORCID: https://orcid.org/0000-0003-0462-9618)
- Marika Vianello (ORCID: https://orcid.org/0009-0006-0864-7230)
- M. Betti (ORCID: https://orcid.org/0000-0001-6621-3971)
- Matilde Inglese
Institutions
- Vita-Salute San Raffaele University (IT)
- Queen Mary University of London (GB)
- University of Cagliari (IT)
- University of Campania "Luigi Vanvitelli" (IT)
- University of Catania (IT)
- University of Chieti-Pescara (IT)
- Azienda Unita' Sanitaria Locale Di Modena (IT)
- Azienda Sanitaria Unità Locale di Reggio Emilia (IT)
- Don Carlo Gnocchi Foundation (IT)
- Istituto delle Scienze Neurologiche di Bologna (IT)
- University of Campania "Luigi Vanvitelli" (IT)
- Ca' Foncello Hospital (IT)
- Ospedale Policlinico San Martino (IT)
- National Hospital for Neurology and Neurosurgery (GB)
- Carlo Forlanini Hospital (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Ospedale San Luigi Gonzaga (IT)
- Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele (IT)
- University of Florence (IT)
- University College London (GB)
- University of Bari Aldo Moro (IT)
- University of Naples Federico II (IT)
- University of Genoa (IT)
- Sapienza University of Rome (IT)
- University of Palermo (IT)
- University of Bologna (IT)
Publication Details
- Journal
- Multiple Sclerosis Journal
- Published
- 2025-06-19
- DOI
- https://doi.org/10.1177/13524585251345317
- Citations
- 1
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.47