Research Progress on Signaling Pathways of LGALS1 in Malignant Tumors

LGALS1 is a protein belonging to the lectin family, widely distributed across immune and non-immune tissues. Characterized by high evolutionary conservation, LGALS1 specifically binds β-galactosides and functions as a multifunctional bioactive protein. It plays pivotal roles in immune regulation, cell migration, and tumor microenvironment remodeling. In malignant tumors, LGALS1 exhibits complex and context-dependent activities. This review systematically examines the downstream signaling pathways modulated by LGALS1—including NF-κB, PI3K/AKT/mTOR, MAPK, Hedgehog, TGF-β, and Wnt—highlighting its dual regulatory roles (promoting or inhibiting tumorigenesis) across cancer types. By synthesizing recent findings, we elucidate the molecular mechanisms underlying LGALS1’s context-specific effects and its influence on key signaling cascades. These insights aim to provide a theoretical framework and research directions for future studies targeting LGALS1 in cancer therapy.