Skeletal Muscle Quantity Versus Quality in Heart Failure: Exercise Intolerance and Outcomes in Older Patients With HFpEF Are Related to Abnormal Skeletal Muscle Metabolism Rather Than Age-Related Skeletal Muscle Loss
EI in older patients with HFpEF is closely linked to age-associated abnormalities in SM energy metabolism, namely, rapid exercise-induced energetic decline and worse energetic profile at fatigue, and not SM quantity. Abnormal SM energy metabolism is associated with worse outcomes in patients with HFpEF in unadjusted analysis. These findings support SM energy metabolism as a barometer of systemic HFpEF severity and the pursuit of new SM metabolic modulators to reduce disabling EI and possibly adverse outcomes in patients with HFpEF.
Authors
- Paul A. Bottomley (ORCID: https://orcid.org/0000-0002-0071-0155)
- Angela Steinberg
- Joseph R. Goldenberg (ORCID: https://orcid.org/0000-0002-9451-8235)
- Gary Gerstenblith (ORCID: https://orcid.org/0000-0001-6046-6812)
- Joevin Sourdon (ORCID: https://orcid.org/0000-0003-4567-8256)
- T. Jake Samuel (ORCID: https://orcid.org/0000-0001-7638-1864)
- Michael Schär (ORCID: https://orcid.org/0000-0002-7044-9941)
- Lisa R. Yanek (ORCID: https://orcid.org/0000-0001-7117-1075)
- Shenghan Lai (ORCID: https://orcid.org/0000-0003-1340-9609)
- Sabra C. Lewsey (ORCID: https://orcid.org/0000-0001-8406-8472)
- Robert G. Weiss (ORCID: https://orcid.org/0000-0002-1844-8677)
Institutions
- University of Maryland, Baltimore (US)
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
- Institute of Human Virology (NG)
- Centre de Résonance Magnétique Biologique et Médicale (FR)
- Resonance Research (United States) (US)
Publication Details
- Journal
- Circulation Heart Failure
- Published
- 2025-06-19
- DOI
- https://doi.org/10.1161/circheartfailure.124.012512
- Citations
- 5
- Primary Topic
- Nutrition and Health in Aging
- Type
- article
- Field-Weighted Citation Impact
- 5.82