Investigation of Poststroke Depression Following a Nucleus Accumbens Infarct in Mice
While no clear PSD phenotype was observed following an ET-1-induced stroke in the NAc of male mice, our study shed light on the technical complexity of focal lesions in deep brain structures, an understudied phenomenon occurring in humans. We provide technical insights for the development of a mouse model of deep brain lesions, characterize its impact at molecular, cellular, and behavioral levels, and highlight the need to control for vascular alterations when performing stroke surgeries.
Authors
- Béatrice Daigle (ORCID: https://orcid.org/0000-0002-2953-9515)
- Luisa Bandeira Binder (ORCID: https://orcid.org/0000-0003-2372-8689)
- Laurence Dion‐Albert (ORCID: https://orcid.org/0000-0002-7051-6390)
- Jonathan Bouchard (ORCID: https://orcid.org/0000-0002-8976-1847)
- Michèle Desjardins (ORCID: https://orcid.org/0000-0003-1112-1628)
- Adeline Collignon (ORCID: https://orcid.org/0009-0005-5086-5648)
- Véronique Rioux
- Caroline Ménard (ORCID: https://orcid.org/0000-0001-8202-7378)
- Martin Lévesque (ORCID: https://orcid.org/0000-0002-1547-3746)
- Manon Lebel (ORCID: https://orcid.org/0000-0003-1649-1214)
- Laura Menegatti Bevilacqua (ORCID: https://orcid.org/0000-0001-6460-0249)
- Vincent St-Arnault
Institutions
- Université Laval (CA)
Publication Details
- Journal
- Stroke
- Published
- 2025-06-19
- DOI
- https://doi.org/10.1161/strokeaha.125.050839
- Citations
- 3
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 3.49