Direct Interleukin-6 Inhibition Blunts Arterial Thrombosis by Reducing Collagen-Mediated Platelet Activation
Direct IL-6 inhibition blunts thrombus formation by reducing collagen-induced platelet activation. These findings offer a potential mechanistic explanation for the results observed in the RESCUE trial and support the rationale of the ongoing ZEUS trial (Ziltivekimab Cardiovascular Outcome Study).
Authors
- Stefano Ministrini (ORCID: https://orcid.org/0000-0003-4358-6411)
- Kilian Kirmes (ORCID: https://orcid.org/0000-0001-6940-0983)
- Jürg H. Beer (ORCID: https://orcid.org/0000-0002-7199-0406)
- Amedeo Tirandi (ORCID: https://orcid.org/0000-0003-1875-0160)
- Fabrizio Montecucco (ORCID: https://orcid.org/0000-0003-0823-8729)
- Susan Bengs (ORCID: https://orcid.org/0000-0003-2424-3894)
- T F Luescher (ORCID: https://orcid.org/0000-0002-5259-538X)
- Peter Libby (ORCID: https://orcid.org/0000-0002-1502-502X)
- Dario Bongiovanni (ORCID: https://orcid.org/0000-0002-4162-1482)
- Giovanni G. Camici (ORCID: https://orcid.org/0000-0002-0523-0695)
- Luca Liberale (ORCID: https://orcid.org/0000-0003-1472-7975)
- Yustina M. Puspitasari (ORCID: https://orcid.org/0000-0001-5448-407X)
- Jiaying Han (ORCID: https://orcid.org/0000-0003-4158-4826)
- R Niederberger
- Leonhard Paul Unkelbach
Institutions
- Brigham and Women's Hospital (US)
- University of Augsburg (DE)
- University Hospital Augsburg (DE)
- TUM Klinikum (DE)
- Harefield Hospital (GB)
- University Hospital of Zurich (CH)
- Molecular Partners (Switzerland) (CH)
- Ospedale Policlinico San Martino (IT)
- University of Genoa (IT)
Publication Details
- Journal
- Arteriosclerosis Thrombosis and Vascular Biology
- Published
- 2025-06-19
- DOI
- https://doi.org/10.1161/atvbaha.125.322533
- Citations
- 3
- Primary Topic
- Atherosclerosis and Cardiovascular Diseases
- Type
- article
- Field-Weighted Citation Impact
- 2.39