Prophylactic proton pump inhibitor use and all-cause mortality in adult sepsis patients: a retrospective analysis based on the MIMIC-IV database
Prophylactic PPI use failed to improve 28-day or 90-day survival rates in adult sepsis patients. Although PPI use was associated with reduced ICU length of stay, it did not shorten total hospital stay duration. Additionally, PPI administration was linked to clinically significant adverse reactions.
Authors
- Min Wang (ORCID: https://orcid.org/0000-0002-1019-2523)
- Lipeng Zhang (ORCID: https://orcid.org/0000-0001-5204-6383)
- Chenchen Ma (ORCID: https://orcid.org/0000-0001-7631-4880)
- Lixin Zhang (ORCID: https://orcid.org/0000-0002-9121-4463)
Institutions
- Anhui Medical University (CN)
- Second Affiliated Hospital of Anhui Medical University (CN)
- Inner Mongolia Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-06-19
- DOI
- https://doi.org/10.3389/fphar.2025.1545533
- Citations
- 1
- Primary Topic
- Sepsis Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- Science and Technology Major Project of Inner Mongolia