Clinicopathological Relevance of Tumor Budding at the Invasive Tumor Front in Early‐Stage Oral Tongue Squamous Cell Carcinoma: Histological and Immunohistochemical Analysis
TB correlates significantly with DOI and perineural invasion. Patients with a high TBI are associated with decreased E-cadherin expression and an increased Ki-67 index. TBI is an independent prognostic factor for the presence of cervical lymphatic metastases, and no association was found between the TBI and DFS or OS.
Authors
- Francisco Alijo Serrano (ORCID: https://orcid.org/0000-0002-8851-3948)
- Ignacio Navarro Cuéllar (ORCID: https://orcid.org/0000-0003-1890-9725)
- Carlos Navarro Cuéllar (ORCID: https://orcid.org/0000-0001-9869-9240)
- Ana María López López (ORCID: https://orcid.org/0000-0003-3284-6759)
- Diego Fernández Acosta
- Borja González Moure
- José Zamorano León
- Samuel Espías Alonso
Institutions
- Universidad Complutense de Madrid (ES)
- Hospital General Universitario Gregorio Marañón (ES)
Publication Details
- Journal
- Head & Neck
- Published
- 2025-06-19
- DOI
- https://doi.org/10.1002/hed.28204
- Primary Topic
- Head and Neck Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00