MODERN APPROACHES TO DIAGNOSIS AND TREATMENT OF SQUAMOUS CELL LARYNX CARCINOMA

THE REVIEW CONSIDERS MODERN EPIDEMIOLOGICAL AND ETIOLOGICAL FEATURES OF SQUAMOUS CELL CARCINOMA OF THE LARYNX (SCLC) AS ONE OF THE MOST COMMON TYPES OF ONCOLOGICAL PATHOLOGY OF THE HEAD AND NECK. FOR THE ANALYSIS, ELECTRONIC INFORMATION DATABASES OF DOMESTIC AND FOREIGN SCIENTIFIC PUBLICATIONS ON THIS TOPIC WERE USED: RESEARCHGATE.NET, ELIBRARY.RU, PUBMED.NCBI.NLM.NIH.GOV, CYBERLENINKA.RU, RESEARCH.BIOMEDCENTRAL.COM AND OTHERS, AS WELL AS OFFICIAL WEBSITES OF SCIENTIFIC JOURNALS IN THE FIELD OF ONCOLOGY FOR 2020-2024. BASED ON THE ANALYSIS, IT WAS NOTED THAT AT PRESENT, SQUAMOUS CELL LARYNX CARCINOMA HAS GOOD PROSPECTS FOR TIMELY DIAGNOSIS AND THERAPY. THE BASIS OF DIAGNOSTIC METHODS IS THE STAGE-BY-STAGE EXAMINATION OF A PATIENT WITH COMPLAINTS OF A CHANGE IN VOICE, COUGH AND SORE THROAT. AFTER SUSPICION OF ONCOLOGICAL PATHOLOGY, BIOPSY WITH IMMUNOHISTOCHEMICAL TESTS, INSTRUMENTAL DIAGNOSTICS WITH LARYNGOSCOPY AND VIBROSTROBOSCOPY, TOMOGRAPHY AND AUTOFLUORESCENCE SPECTROSCOPY ARE NECESSARY. THE SCLC THERAPY IS BASED ON SURGICAL TREATMENT METHODS SUPPLEMENTED BY ANTITUMOR RADIATION THERAPY AND CHEMOTHERAPY WITH PLATINUM DRUGS, TAXANES, MONOCLONAL ANTIBODIES, TARGETED DRUGS IN ORDER TO ACHIEVE TARGETED KNOCKDOWN OF CERTAIN GENES AND PROTEINS. THE REVIEW MAY BE USEFUL FOR DEVELOPING A PLAN FOR MANAGING PATIENTS WITH SQUAMOUS CELL LAR-YNX CARCINOMA TO IMPROVE DIAGNOSTIC AND THERAPEUTIC STRATEGIES.