Formulation and Evaluation of Voglibose Mouth Dissolving Tablets

Mouth dissolving tablets are solid dosage forms which break down in the oral cavity less than one minute without using of water. These dosage forms are placed in the mouth, allowable to diffuse or melt in the saliva.Mouth dissolving Voglibose tablets offer a convenient and patientfriendly alternative to traditional tablets for the management of type 2 diabetes mellitus. With their rapid disintegration and absorption, these tablets provide a quick and effective way to control postprandial blood glucose levels. Voglibose is alpha glycosidase inhibitor, drug which is used in a treatment of type 2 diabetes mellitus.The study was aimed at development of voglibose mouth dissolving tablets which can disintegrate or dissolve rapidly once place in the oral cavity. The tablets were prepared with different super disintegrant like crospovidone, sodium starch glycolate and lactose at different concentrations. The blend was evaluated for angle of repose, bulk density, tapped density, carr’s index, Hausner’s ratio. The tablets were evaluated for hardness, friability, weight variation, content uniformity test, disintegration test, wetting time. The optimized formulation exhibited excellent disintegration time and dissolution profile, meeting the pharmacopoeia requirements for MDTs. Furthermore, sensory evaluation revealed improved palatability compared to conventional tablets. Thus, the developed MDT of Voglibose offers a promising alternative for enhancing patient compliance and convenience in the management of diabetes mellitus. The tablets were evaluated for hardness, friability, weight variation, content uniformity test, disintegration test, wetting time