Formulation and Optimization of Fast Dissolving Tablets of Omeprazole Using Design of Experiments (DoE) Approach

Objective The main objective of this study was to formulate and evaluate fast dissolving tablets of Omeprazole using direct compression and wet granulation methods and to compare their performance based on various physicochemical parameters and compare the drug release profiles of different formulations to identify the most effective formulation for rapid disintegration and maximum drug release. Method Formulations were developed using direct compression method and formulation variables such as superdisintegrant and binder concentrations were optimized using Box-Behnken Design (BBD). The tablets were evaluated for pre-compression and post-compression parameters such as hardness, friability, weight variation, wetting time, disintegration time, and in-vitro drug release. Drugexcipient compatibility was confirmed through FTIR analysis. Result The optimized formulation showed a drug release of 99.97% within 12 minutes and rapid disintegration. In contrast, wet granulation tablets had higher hardness but slower disintegration, making them less suitable for fast release. Conclusion The study concludes that the direct compression method, particularly with crospovidone superdisintegrants , is the most effective technique for formulating Omeprazole fast dissolving tablets. This formulation offers rapid disintegration and enhanced drug release, making it a suitable alternative for conventional oral dosage forms.