Formulation and Evaluation of Immediate Release tablets of Bedaquiline

The development of immediate-release tablets of Bedaquiline aims to enhance its therapeuticefficacy in the treatment of multidrug-resistant tuberculosis (MDR-TB). This study focuses on theformulation and evaluation of immediate-release tablets using wet granulation technique. Variousexcipients were employed to achieve rapid disintegration and improved bioavailability. Pre-formulation studies were conducted to assess the physicochemical properties of Bedaquiline,including solubility, compatibility excipients, and flow properties. Tablets were formulated usinga combination of superdisintegrants like croscarmellose sodium and sodium starch glycolate to ensureimmediate drug release. The formulations were evaluated for key parameters, including weightuniformity, hardness, friability, disintegration time, and dissolution profile. The optimized formulationexhibited rapid disintegration within 30 seconds and demonstrated more than 85% drug release withinthe first 30 minutes, complying with the pharmacopeial standards. Stability studies conducted underaccelerated conditions indicated no significant changes in the physicochemical properties or drugrelease profile. The study concludes that immediate-release tablets of Bedaquiline can provide apromising approach to improve patient compliance and therapeutic outcomes in MDR-TB treatmentby ensuring rapid onset of action and optimal drug delivery