Pre-Clinical Evaluation of Therapeutic Potential of Prunetin as a Hepatoprotective Agent

The term “hepatoprotective” describes a substance’s capacity to shield the liver from harm. This may entail lowering inflammation, encouraging liver cell regeneration, or limiting damage from toxins. The current study's findings indicated that prunetin had phenolic content, proteins, amino acids, sterols, glycosides, saponins, flavonoids, alkaloids, and carbs. Of all the flavonoids, prunetin's hepatoprotective action is caused by glycosides and phenolic compounds. To determine the appropriate dosage of the non-toxic prunetin, additional acute toxicity research was conducted. According to an acute toxic research, the safe doses are 20 mg/kg and 40 mg/kg.

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Publication Details

Journal
International Journal of Pharmaceutical Research and Applications
Published
2025-03-01
DOI
https://doi.org/10.35629/4494-100316171640
Primary Topic
Drug-Induced Hepatotoxicity and Protection
Type
article
Field-Weighted Citation Impact
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article

Pre-Clinical Evaluation of Therapeutic Potential of Prunetin as a Hepatoprotective Agent

Abdul Hameed, Hina Afaq, Yash Srivastav, Divya Singh
International Journal of Pharmaceutical Research and Applications
Drug-Induced Hepatotoxicity and Protection
article

Pre-Clinical Evaluation of Therapeutic Potential of Prunetin as a Hepatoprotective Agent

Abdul Hameed, Hina Afaq, Yash Srivastav, Divya Singh
article en

Abstract

The term “hepatoprotective” describes a substance’s capacity to shield the liver from harm. This may entail lowering inflammation, encouraging liver cell regeneration, or limiting damage from toxins. The current study's findings indicated that prunetin had phenolic content, proteins, amino acids, sterols, glycosides, saponins, flavonoids, alkaloids, and carbs. Of all the flavonoids, prunetin's hepatoprotective action is caused by glycosides and phenolic compounds. To determine the appropriate dosage of the non-toxic prunetin, additional acute toxicity research was conducted. According to an acute toxic research, the safe doses are 20 mg/kg and 40 mg/kg.

International Journal of Pharmaceutical Research and ApplicationsVol. 10(3)
Good health and well-being
Openalex Percentile: Top 81%
Drug-Induced Hepatotoxicity and Protection
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