Evaluating the Efficacy of Astragaloside IV and Neferine Combination on Lung Cancer Through Inactivation of the Wnt/-Catenin Signaling Pathway

Lung cancer is a serious disease that ends numerous lives throughout the world. Surgery and chemotherapy are often used in treating cancer nowadays, but they are overly aggressive especially for the elderly and can result in unsatisfactory outcomes like painful side-effects, drug resistance, etc. With the modernization of traditional Chinese medicine (TCM) and increasing evidence that indicates TCM has essential anticancer components. Astragaloside IV and Neferine are considered as two main effective ingredients in Astragalus membranaceus and Nelumbo nucifera. Astragalus membranaceus and Nelumbo nucifera have traditionally been used for various diseases such as fever, inflammation, insomnia, nervous disorders, et al. Thus, as TCM, Astragaloside IV and Neferine can be a potential new weapon for lung cancer which has much less side-effects. In this research, we studied the effect of Astragaloside IV and Neferine on the Wnt /-catenin signaling pathway which is closely related to the occurrence of lung cancer.