Dosimetric Comparison of VMAT Alone and VMAT with HDR Brachytherapy Boost Using Clinical and Biological Dose Models in Localized Prostate Cancer
This study underscores the value of radiobiological modeling in differentiating and optimizing prostate cancer radiotherapy strategies. While the trade-offs between dose escalation and OAR sparing are clinically known, our biologically driven analysis provides a more quantitative foundation for selecting and tailoring combined EBRT/HDR-BT regimens in practice.
Authors
- Andrea Hille
- Sandra Donath
- Manuel Guhlich (ORCID: https://orcid.org/0000-0002-2599-6196)
- Arne Strauß (ORCID: https://orcid.org/0000-0002-4379-1792)
- Markus Schirmer (ORCID: https://orcid.org/0000-0003-1375-4496)
- Laura Anna Fischer
- Olga Knaus
- Annemarie Uhlig (ORCID: https://orcid.org/0000-0001-7305-9271)
- Martin Leu (ORCID: https://orcid.org/0000-0002-3883-6837)
- Jann Fischer (ORCID: https://orcid.org/0009-0002-8826-5662)
- Leif H. Dröge (ORCID: https://orcid.org/0000-0002-5378-4246)
- Stefan Rieken (ORCID: https://orcid.org/0009-0000-7018-2856)
- Stephanie Bendrich (ORCID: https://orcid.org/0009-0001-6562-6616)
Institutions
- Universitätsmedizin Göttingen (DE)
- University of Göttingen (DE)
Publication Details
- Journal
- Current Oncology
- Published
- 2025-06-19
- DOI
- https://doi.org/10.3390/curroncol32060360
- Primary Topic
- Prostate Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00