Comprehensive Overview: The History, Structure, Composition, and Mechanism of Ibuprofen

One typical non-steroidal anti-inflammatory medicine (NSAID) in the home is ibuprofen and this paper will discuss the aforementioned organic compound. In this work, the history, structure and composition, mechanism, binding and metabolism of ibuprofen are covered. The two researchers will attempt to explain different stages of the development of the drug as well as research surrounding the drug. Afterwards, the paper will cover functional groups, bonds, enantiomers of the drug. Lastly, the paper will delve into the more intricate workings of ibuprofen including the process of different synthesis of prostaglandin, ranging from PGF2, PGE2, PGD2 to TXA2, distribution of different prostaglandins in different human issues and functions of prostaglandins, differences between COX-1 and COX-2, how COX is binded, and primary and secondary metabolism.

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Publication Details

Journal
Theoretical and Natural Science
Published
2025-06-19
DOI
https://doi.org/10.54254/2753-8818/2025.24230
Primary Topic
Inflammatory mediators and NSAID effects
Type
article
Field-Weighted Citation Impact
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article

Comprehensive Overview: The History, Structure, Composition, and Mechanism of Ibuprofen

Ziyan Liu, Zirong Jiang
Theoretical and Natural Science
Inflammatory mediators and NSAID effects
article

Comprehensive Overview: The History, Structure, Composition, and Mechanism of Ibuprofen

Ziyan Liu, Zirong Jiang
article en

Abstract

One typical non-steroidal anti-inflammatory medicine (NSAID) in the home is ibuprofen and this paper will discuss the aforementioned organic compound. In this work, the history, structure and composition, mechanism, binding and metabolism of ibuprofen are covered. The two researchers will attempt to explain different stages of the development of the drug as well as research surrounding the drug. Afterwards, the paper will cover functional groups, bonds, enantiomers of the drug. Lastly, the paper will delve into the more intricate workings of ibuprofen including the process of different synthesis of prostaglandin, ranging from PGF2, PGE2, PGD2 to TXA2, distribution of different prostaglandins in different human issues and functions of prostaglandins, differences between COX-1 and COX-2, how COX is binded, and primary and secondary metabolism.

Theoretical and Natural ScienceVol. 115(1)
John L. Miller Great Neck North High School (US), Shanghai Jinyuan Senior High School (CN)
Good health and well-being
Openalex Percentile: Top 84%
Inflammatory mediators and NSAID effects
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Comprehensive Overview: The History, Structure, Composition, and Mechanism of Ibuprofen — Ziyan Liu, Zirong Jiang · Theoretical and Natural Science (2025) | TGRS Research Map | TGRS