Comparative Analysis of Amoxicillin and Clarithromycin in Triple Therapy for Helicobacter Pylori-Induced Peptic Ulcers

Peptic ulcer is a medical condition commonly found in the stomach or upper area of the small intestine (duodenum) caused by a specific bacterium, Helicobacter pylori, known as H. pylori. This study's main purpose is to provide a comparative analysis of three different treatments against peptic ulcers and their optimal usages: amoxicillin, clarithromycin, and a combination of the two with a proton pump inhibitor (PPI), triple therapy. While amoxicillin is preferred for initial treatment due to its reduced side effects and broader accessibility, clarithromycin has demonstrated higher eradication rates against H. Pylori. Among the three interventions, triple therapy provides the most complete eradication by using a PPI to lower antibiotic pH, enhancing the effectiveness of antibiotics and eliminating bacterial infections.