A Comparison of Representative Drugs Under Two Existing Treatment Strategies for Alzheimer's Disease

This paper introduces two primary therapeutic approaches for Alzheimer's disease: symptom-improving drugs and disease-modifying treatments by comparing the specific drugs Donepezil and Aducanumab. Aducanumab, as the first disease-modifying treatment for Alzheimer's disease approved in more than two decades, marks the beginning of A monoclonal antibody therapy efforts. Introducing this "pioneer" provides a fitting context to discuss symptom-improving treatments. Donepezil is a drug commonly used to relieve symptoms. It is considered to be more suitable for patients with earlier stages of the disease than similar drugs such as memantine. Therefore, it was the better choice when comparing the two drugs in this review. By comparing these two treatments, we can better assess their effectiveness in treating Alzheimer's disease and their suitability for different clinical situations. This comparison helps to identify common treatment strategies for Alzheimer's disease.

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Publication Details

Journal
Theoretical and Natural Science
Published
2025-06-19
DOI
https://doi.org/10.54254/2753-8818/2025.24223
Primary Topic
Cholinesterase and Neurodegenerative Diseases
Type
article
Field-Weighted Citation Impact
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article

A Comparison of Representative Drugs Under Two Existing Treatment Strategies for Alzheimer's Disease

Yan Zhong
2 links
Theoretical and Natural Science
Cholinesterase and Neurodegenerative Diseases
article

A Comparison of Representative Drugs Under Two Existing Treatment Strategies for Alzheimer's Disease

Yan Zhong
article en

Abstract

This paper introduces two primary therapeutic approaches for Alzheimer's disease: symptom-improving drugs and disease-modifying treatments by comparing the specific drugs Donepezil and Aducanumab. Aducanumab, as the first disease-modifying treatment for Alzheimer's disease approved in more than two decades, marks the beginning of A monoclonal antibody therapy efforts. Introducing this "pioneer" provides a fitting context to discuss symptom-improving treatments. Donepezil is a drug commonly used to relieve symptoms. It is considered to be more suitable for patients with earlier stages of the disease than similar drugs such as memantine. Therefore, it was the better choice when comparing the two drugs in this review. By comparing these two treatments, we can better assess their effectiveness in treating Alzheimer's disease and their suitability for different clinical situations. This comparison helps to identify common treatment strategies for Alzheimer's disease.

Theoretical and Natural ScienceVol. 115(1)
Central South University (CN)
Good health and well-being
Openalex Percentile: Top 84%
Cholinesterase and Neurodegenerative Diseases
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A Comparison of Representative Drugs Under Two Existing Treatment Strategies for Alzheimer's Disease — Yan Zhong · Theoretical and Natural Science (2025) | TGRS Research Map | TGRS