Evaluation of reported claims of sex-based differences in treatment effects across meta-analyses: a meta-research study
Few meta-analyses of RCTs make claims of sex-based differences in treatment effects, and most of these claims lack formal statistical support. In the present sample, statistically significant and clinically actionable sex-treatment interactions were rare.
Authors
- Lia Bally (ORCID: https://orcid.org/0000-0003-1993-7672)
- Erand Llanaj (ORCID: https://orcid.org/0000-0003-4300-0433)
- Hamidreza Raeisi‐Dehkordi (ORCID: https://orcid.org/0000-0002-5538-6073)
- Taulant Muka (ORCID: https://orcid.org/0000-0003-3235-3073)
- John P. A. Ioannidis (ORCID: https://orcid.org/0000-0003-3118-6859)
- Sara Farina (ORCID: https://orcid.org/0000-0002-9853-5278)
- Hugo G. Quezada‐Pinedo (ORCID: https://orcid.org/0000-0002-0641-7718)
- Lum Kastrati (ORCID: https://orcid.org/0000-0001-5759-1479)
- Angelica Valz Gris (ORCID: https://orcid.org/0000-0001-7227-2281)
Institutions
- Università Cattolica del Sacro Cuore (IT)
- University of Bern (CH)
- Duke University (US)
- Utrecht University (NL)
- University Hospital of Bern (CH)
- University Medical Center Utrecht (NL)
- Deutsches Diabetes-Zentrum e.V. (DE)
- German Center for Diabetes Research (DE)
- German Institute of Human Nutrition (DE)
- Heinrich Heine University Düsseldorf (DE)
- Stanford University (US)
Publication Details
- Journal
- BMJ evidence-based medicine
- Published
- 2025-06-19
- DOI
- https://doi.org/10.1136/bmjebm-2024-113359
- Primary Topic
- Sex and Gender in Healthcare
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Inselspital, Universitätsspital Bern