Enhancing selective itaconic acid synthesis in Yarrowia lipolytica through targeted metabolite transport reprogramming
By integrating transporter engineering and pathway diversification, this study demonstrates an effective strategy to enhance itaconic acid production in Y. lipolytica while minimising by-product formation. The findings provide new insights into organic acid transport in yeast and open avenues for further optimization of microbial cell factories for sustainable biochemical production.
Authors
- Cosetta Ciliberti
- Evgeniya Y. Yuzbasheva (ORCID: https://orcid.org/0000-0003-4358-4205)
- I. G. Laptev (ORCID: https://orcid.org/0000-0002-1893-2055)
- Isabella Pisano (ORCID: https://orcid.org/0000-0003-0728-2226)
- Zbigniew Lazar (ORCID: https://orcid.org/0000-0001-7315-1983)
- Tigran V. Yuzbashev (ORCID: https://orcid.org/0000-0002-0522-6055)
- Luigi Palmieri (ORCID: https://orcid.org/0000-0002-6503-2922)
- Gennaro Agrimi (ORCID: https://orcid.org/0000-0002-5219-4412)
- Kacper Szymański (ORCID: https://orcid.org/0000-0001-7380-6978)
Institutions
- Altera (United States) (US)
- Rothamsted Research (GB)
- West Hertfordshire Hospitals NHS Trust (GB)
- Institute of Agricultural and Food Biotechnology (PL)
- Consorzio Interuniversitario per le Biotecnologie (IT)
- University of Bari Aldo Moro (IT)
Publication Details
- Journal
- Biotechnology for Biofuels and Bioproducts
- Published
- 2025-06-19
- DOI
- https://doi.org/10.1186/s13068-025-02668-9
- Citations
- 3
- Primary Topic
- Microbial Metabolic Engineering and Bioproduction
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- European Commission
- Ministero dell’Istruzione, dell’Università e della Ricerca
- Universita degli Studi di Bari Aldo Moro