The Use of Hyprojoint as Facial Dermal Skin Booster: Safety Tolerability and Effectiveness on a 25 Patient Sample

Skin aging is a multifaceted process influenced by intrinsic and extrinsic factors. Hyaluronic Acid (HA) plays a crucial role in skin hydration and is widely used in dermatology for its ability to improve skin quality. This study evaluated the tolerability and safety of off-label intradermal injections of Hyprojoint, a medium-high molecular weight HA solution, in 25 healthy volunteers (aged 40-66 years) exhibiting signs of chronological and photo-aging. A mesotherapy technique was used to administer 2.5 mL of Hyprojoint every four weeks. Objective and subjective assessments were performed at baseline, 21 days and 60 days. Results showed statistically significant improvements in skin aging signs: A 25% reduction in mean wrinkle depth in the periorbital area (p < 0.05), a 40% increase in mean skin smoothness in the cheek area (p < 0.01) and a 45% increase in mean skin hydration across all treated areas (p < 0.05). These improvements are attributed to HA’s water-retention capacity and its stimulation of collagen and elastin production. The treatment was well-tolerated with no significant adverse events, suggesting Hyprojoint could be a viable option for improving skin quality, even with off-label use.