Basement membrane repair response biomarker PRO-C4 predicts progression in idiopathic pulmonary fibrosis: analysis of the PFBIO and PROFILE cohorts
High and increasing serological PRO-C4 levels were prognostic for progression in two independent IPF cohorts. This study suggests that COL4 synthesis assessed by PRO-C4 is a pathologically relevant biomarker of alveolar BM repair in IPF.
Authors
- Peder Frederiksen
- Elisabeth Bendstrup (ORCID: https://orcid.org/0000-0002-4238-6963)
- Simon R. Johnson (ORCID: https://orcid.org/0000-0002-9837-2763)
- Gísli Jenkins (ORCID: https://orcid.org/0000-0002-7929-2119)
- Thomas Skovhus Prior (ORCID: https://orcid.org/0000-0002-0668-8454)
- Iain D. Stewart (ORCID: https://orcid.org/0000-0002-1340-2688)
- Filipa B. Simões (ORCID: https://orcid.org/0000-0003-2010-1282)
- Hernan P. Fainberg (ORCID: https://orcid.org/0000-0001-9330-9047)
- Alison E. John (ORCID: https://orcid.org/0000-0002-0453-3221)
- Diana Julie Leeming (ORCID: https://orcid.org/0000-0002-4256-140X)
- Toby M. Maher (ORCID: https://orcid.org/0000-0001-7192-9149)
- Philip L. Molyneaux (ORCID: https://orcid.org/0000-0003-1301-8800)
- M.A. Karsdal (ORCID: https://orcid.org/0000-0001-5026-8740)
- Jannie Marie Bülow Sand (ORCID: https://orcid.org/0000-0002-3239-0934)
- Nils Hoyer (ORCID: https://orcid.org/0000-0003-4395-1837)
- Adnan Avdic-Belltheus
- Saher Burhan Shaker
Institutions
- University of Southern California (US)
- Aarhus University Hospital (DK)
- Gentofte Hospital (DK)
- Nordic Bioscience (Denmark) (DK)
- Nottingham Biomedical Research Centre (GB)
- Imperial College London (GB)
Publication Details
- Journal
- Thorax
- Published
- 2025-06-19
- DOI
- https://doi.org/10.1136/thorax-2024-221868
- Citations
- 3
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 4.56
Funders
- Medical Research Council