Using prodromal non-motor symptoms to predict Parkinson’s disease onset and motor phenotype
In this exploratory analysis, individuals with prodromal hyposmia and anxiety phenoconverted to PD sooner and more often had a non-tremor-dominant phenotype, potentially reflecting more widespread pathology or specific pathophysiology underlying these symptoms. This may improve phenotyping prodromal PD and stratifying poorer prognostic trajectories for earlier and more personalised management.
Authors
- James Badenoch (ORCID: https://orcid.org/0000-0002-6994-6916)
- Daniel J. van Wamelen (ORCID: https://orcid.org/0000-0003-0921-5158)
- Joshua Pearson (ORCID: https://orcid.org/0009-0009-9862-5597)
Institutions
- King's College London (GB)
- South London and Maudsley NHS Foundation Trust (GB)
- Pearson (United Kingdom) (GB)
- King's College Hospital NHS Foundation Trust (GB)
Publication Details
- Journal
- Journal of Neurology Neurosurgery & Psychiatry
- Published
- 2025-06-19
- DOI
- https://doi.org/10.1136/jnnp-2024-335429
- Citations
- 2
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.78