Targeting Stearoyl‐CoA Desaturase 1 Through PI3K‐AKT‐mTOR Signaling in Head and Neck Squamous Cell Carcinoma
SCD1 is a downstream target of the PI3K-AKT-mTOR pathway and contributes to HNSCC cell survival. Dual targeting of SCD1 and the mTOR signaling pathway represents a promising therapeutic strategy for HNSCC treatment. Further investigation is warranted to explore the clinical potential of SCD1 inhibitors in combination with mTOR-targeted therapies.
Authors
- Ming‐Yu Yang (ORCID: https://orcid.org/0000-0002-6841-5478)
- Shun‐Fu Chang (ORCID: https://orcid.org/0000-0002-2276-7785)
- Hui‐Chen Su (ORCID: https://orcid.org/0000-0002-1482-8664)
- Cheng‐Ming Hsu (ORCID: https://orcid.org/0000-0003-3792-3784)
Institutions
- Chang Gung University (TW)
- Kaohsiung Chang Gung Memorial Hospital (TW)
- Xiamen Chang Gung Hospital (CN)
- Chiayi Chang Gung Memorial Hospital (TW)
- National Cheng Kung University Hospital (TW)
Publication Details
- Journal
- OTO Open
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1002/oto2.70143
- Citations
- 2
- Primary Topic
- Cancer, Lipids, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- Chang Gung Medical Foundation
- National Science and Technology Council