Total synthesis and algaecidal activity of questiomycins against harmful bloom forming dinoflagellates
We report the total synthesis of questiomycins A, C-E and analogues, and their algaecidal activity against three harmful bloom- and toxin-forming algae: <i>Karenia brevis</i>, <i>Prorocentrum cordatum</i>, and <i>Amphidinium carterae</i>. Structure-activity relationship studies revealed potent derivatives with distinct modes of action, signalling their potential as targeted agents for harmful algal bloom control.
Authors
- Bryndan P. Durham (ORCID: https://orcid.org/0000-0002-2253-157X)
- Yanfei Wang (ORCID: https://orcid.org/0000-0002-4919-3945)
- Spencer J. Williams (ORCID: https://orcid.org/0000-0001-6341-4364)
- Laura Burchill (ORCID: https://orcid.org/0000-0003-0959-7248)
- Wei-Yang Bao (ORCID: https://orcid.org/0000-0001-6709-269X)
- Niraj Aryal
- Siti Nur Qamarina Binti Azmi
- Laurel E. Meke
Institutions
- The University of Melbourne (AU)
- University of Florida (US)
- University of Delaware (US)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc02853a
- Primary Topic
- Marine Toxins and Detection Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Simons Foundation
- University of Florida
- Australian Academy of Science
- National Oceanic and Atmospheric Administration
- Australian Research Council