Cardiac Myxoma Post-Transseptal Ablation: Coincidence or Causation?

Background: Cardiac myxomas are benign cardiac neoplasms usually found solitarily located within a single cardiac chamber, most commonly in the left atrium. With no established cause, they are often thought to occur spontaneously with no particular genetic cause or external incitement. While it has been explored, there is no universally accepted correlation with myxoma formation following a cardiac ablation procedure. We propose the theory of an iatrogenic causation of cardiac myxoma formation, likely incited by the local tissue injury during the transseptal puncture of the interatrial wall. Case Summary: We present the case of a 62-year-old male with a medical history significant for Atrial Fibrillation for which he underwent a transseptal ablation procedure, during which a puncture is made through the interatrial septum. Transthoracic and transesophageal echocardiograms obtained prior to the procedure did not reveal any intracardiac masses or abnormalities. 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