BNIP3 induced by hypoxia supports the survival of mesenchymal stromal cells (MSCs) after intravenous cell transplantation
This suggests that cell culture under hypoxia facilitates accumulation of Bnip3, a key regulator of mitophagy and confers stress tolerance to the MSCs. The findings indicate that pre-treating MSCs in hypoxic environment prior to transplantation could be a simple and effective strategy to improve cell viability in cell transplantation therapy.
Authors
- Kei Houri (ORCID: https://orcid.org/0000-0002-1712-0530)
- Toshiyuki Takehara (ORCID: https://orcid.org/0000-0001-5790-2978)
- Shinichiro Miyoshi
- Fumie Ikebuchi
- Kanae Shigi
- Natsumi Iwawaki
- Tatsufumi Mori
- Yoshiyuki Tago
- Takeshi Teramura (ORCID: https://orcid.org/0000-0002-5310-4749)
- Takatoshi Tsujimoto
Institutions
- Kaneka (United States) (US)
- Kaneka (Japan) (JP)
- Cyber Laser (Japan) (JP)
- Kindai University (JP)
Publication Details
- Journal
- Regenerative Therapy
- Published
- 2025-06-19
- DOI
- https://doi.org/10.1016/j.reth.2025.06.005
- Primary Topic
- Mesenchymal stem cell research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministry of Education, Culture, Sports, Science and Technology
- Japan Society for the Promotion of Science