Evaluation of Emetogenic Mechanisms of Antineoplastic Drugs on 5-HT3A Receptor Using a Structure-Based Computational Approach
Chemotherapy-induced nausea and vomiting are known to result indirectly from serotonin released by damaged intestinal cells in response to the toxic side effects of chemotherapy drugs. However, this study remarkably proposes an alternative mechanism for CINV and presents the first evidence of a direct interaction between certain antineoplastic drugs and the serotonin receptor.
Authors
- Zihni Onur Çalışkaner (ORCID: https://orcid.org/0000-0003-1385-1739)
Institutions
- Biruni University (TR)
Publication Details
- Journal
- Journal of Clinical Practice and Research
- Published
- 2025-01-01
- DOI
- https://doi.org/10.14744/cpr.2025.49099
- Primary Topic
- Receptor Mechanisms and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00